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Sheehan syndrome

MedGen UID:
116569
Concept ID:
C0242342
Disease or Syndrome
Synonyms: Postpartum hypopituitarism; Postpartum panhypopituitarism; Postpartum panhypopituitary syndrome; Postpartum pituitary necrosis; Simmond's disease
SNOMED CT: Sheehan syndrome (237684005); Sheehan's syndrome (237684005); Postpartum pituitary necrosis (237684005); Postpartum hypopituitarism (290653008); Simmond's disease (32390006); Simmonds' disease (32390006)
 
Monarch Initiative: MONDO:0019618
Orphanet: ORPHA91355

Definition

Sheehan syndrome is a rare, acquired, pituitary hormone deficiency disorder resulting from pituitary necrosis following peri- or postpartum hemorrhage characterized by various symptoms depending on resulting hormone decrease (e.g. failure or difficulty with lactation, oligo- or amenorrhea, hot flashes, decreased libido, weakness, fatigue, anorexia, nausea, vomiting, hypoglycemia, hyponatremia, dizziness, decreased muscle mass, adrenal crisis). Secondary hypothyroidism and secondary adrenal insufficiency may also be presenting signs. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSheehan syndrome
Follow this link to review classifications for Sheehan syndrome in Orphanet.

Professional guidelines

PubMed

Kerns J, Itriyeva K, Fisher M
Curr Probl Pediatr Adolesc Health Care 2022 May;52(5):101184. Epub 2022 May 4 doi: 10.1016/j.cppeds.2022.101184. PMID: 35525789
Committee on Practice Bulletins-Obstetrics
Obstet Gynecol 2017 Oct;130(4):e168-e186. doi: 10.1097/AOG.0000000000002351. PMID: 28937571
American College of Obstetricians and Gynecologists
Obstet Gynecol 2006 Oct;108(4):1039-47. doi: 10.1097/00006250-200610000-00046. PMID: 17012482

Recent clinical studies

Etiology

Laway BA, Baba MS
Front Endocrinol (Lausanne) 2023;14:1086731. Epub 2023 Jan 20 doi: 10.3389/fendo.2023.1086731. PMID: 36742387Free PMC Article
Kodama K, Ichihara A, Seki Y, Ikarashi Y, Sagawa T, Kogiso T, Taniai M, Tokushige K
Can J Gastroenterol Hepatol 2020;2020:8814435. Epub 2020 Oct 10 doi: 10.1155/2020/8814435. PMID: 33102399Free PMC Article
Honegger J, Giese S
Minerva Endocrinol 2018 Dec;43(4):465-475. Epub 2018 Feb 19 doi: 10.23736/S0391-1977.18.02814-6. PMID: 29463076
Committee on Practice Bulletins-Obstetrics
Obstet Gynecol 2017 Oct;130(4):e168-e186. doi: 10.1097/AOG.0000000000002351. PMID: 28937571
American College of Obstetricians and Gynecologists
Obstet Gynecol 2006 Oct;108(4):1039-47. doi: 10.1097/00006250-200610000-00046. PMID: 17012482

Diagnosis

Mandal S, Mukhopadhyay P, Ghosh S
Endocr Pract 2021 Dec;27(12):1212-1215. Epub 2021 Jul 24 doi: 10.1016/j.eprac.2021.07.013. PMID: 34311117
Laway BA, Baba MS
J Pak Med Assoc 2021 Apr;71(4):1282-12568. PMID: 34125791
Chanson P
Endocrinol Metab Clin North Am 2019 Sep;48(3):583-603. Epub 2019 Jun 18 doi: 10.1016/j.ecl.2019.05.005. PMID: 31345525
Woodmansee WW
Neurol Clin 2019 Feb;37(1):63-83. doi: 10.1016/j.ncl.2018.09.009. PMID: 30470276
American College of Obstetricians and Gynecologists
Obstet Gynecol 2006 Oct;108(4):1039-47. doi: 10.1097/00006250-200610000-00046. PMID: 17012482

Therapy

Lu Y, Wei R, Li S, Peng L, Shi Z
Altern Ther Health Med 2023 Mar;29(2):218-223. PMID: 36480677
Mandal S, Mukhopadhyay P, Ghosh S
J Clin Endocrinol Metab 2022 Jul 14;107(8):e3395-e3402. doi: 10.1210/clinem/dgac260. PMID: 35481572
Bing X, Peifang L
Cancer Rep (Hoboken) 2019 Aug;2(4):e1171. Epub 2019 Apr 21 doi: 10.1002/cnr2.1171. PMID: 32721123Free PMC Article
Matsuwaki T, Khan KN, Inoue T, Yoshida A, Masuzaki H
J Obstet Gynaecol Res 2014 Jan;40(1):46-52. Epub 2013 Aug 15 doi: 10.1111/jog.12119. PMID: 23945005
Yamada M, Mori M
Nat Clin Pract Endocrinol Metab 2008 Dec;4(12):683-94. Epub 2008 Oct 21 doi: 10.1038/ncpendmet0995. PMID: 18941435

Prognosis

Lu Y, Wei R, Li S, Peng L, Shi Z
Altern Ther Health Med 2023 Mar;29(2):218-223. PMID: 36480677
Olmes GL, Solomayer EF, Radosa JC, Sklavounos P, Agne P, Schunk SJ, Haj Hamoud B
Arch Gynecol Obstet 2022 Sep;306(3):699-706. Epub 2021 Nov 15 doi: 10.1007/s00404-021-06294-2. PMID: 34779875Free PMC Article
Chanson P
Endocrinol Metab Clin North Am 2019 Sep;48(3):583-603. Epub 2019 Jun 18 doi: 10.1016/j.ecl.2019.05.005. PMID: 31345525
Kanekar S, Bennett S
Radiographics 2016 Nov-Dec;36(7):2102-2122. doi: 10.1148/rg.2016150187. PMID: 27831835
Matsuwaki T, Khan KN, Inoue T, Yoshida A, Masuzaki H
J Obstet Gynaecol Res 2014 Jan;40(1):46-52. Epub 2013 Aug 15 doi: 10.1111/jog.12119. PMID: 23945005

Clinical prediction guides

Mandal S, Mukhopadhyay P, Ghosh S
Endocr Pract 2021 Dec;27(12):1212-1215. Epub 2021 Jul 24 doi: 10.1016/j.eprac.2021.07.013. PMID: 34311117
Cavalcante DD, Pinto-Quidute AR, Alves-Martins MR, Walter-de-Aguiar AS, Lima-Cid AM, Silva PG, Cavalcante RF, Costa FW
Med Oral Patol Oral Cir Bucal 2018 Jul 1;23(4):e436-e442. doi: 10.4317/medoral.22377. PMID: 29924763Free PMC Article
Honegger J, Giese S
Minerva Endocrinol 2018 Dec;43(4):465-475. Epub 2018 Feb 19 doi: 10.23736/S0391-1977.18.02814-6. PMID: 29463076
Committee on Practice Bulletins-Obstetrics
Obstet Gynecol 2017 Oct;130(4):e168-e186. doi: 10.1097/AOG.0000000000002351. PMID: 28937571
Matsuwaki T, Khan KN, Inoue T, Yoshida A, Masuzaki H
J Obstet Gynaecol Res 2014 Jan;40(1):46-52. Epub 2013 Aug 15 doi: 10.1111/jog.12119. PMID: 23945005

Recent systematic reviews

Olmes GL, Solomayer EF, Radosa JC, Sklavounos P, Agne P, Schunk SJ, Haj Hamoud B
Arch Gynecol Obstet 2022 Sep;306(3):699-706. Epub 2021 Nov 15 doi: 10.1007/s00404-021-06294-2. PMID: 34779875Free PMC Article

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